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Potent Inhibition of the Master Chondrogenic FactorSox9 Gene by Interleukin-1 and Tumor Necrosis Factor-α

1 Feb 2000

Abstract excerpt

The inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) strongly inhibit the expression of genes for cartilage extracellular matrix proteins. We have recently obtained genetic evidence indicating that the high mobility group domain containing transcription factor Sox9 is required for cartilage formation and for expression of chondrocyte-specific genes including the gene for...

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PMID: 10652367
DOI: 10.1074/jbc.275.5.3687

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Related research

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Potent Inhibition of the Master Chondrogenic FactorSox9 Gene by Interleukin-1 and Tumor Necrosis Factor-αPMID 10652367Read ↗

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Regulation of SOX9 mRNA in Human Articular Chondrocytes Involving p38 MAPK Activation and mRNA StabilizationSemantic proximity Read ↗

SOX9 and the many facets of its regulation in the chondrocyte lineageSemantic proximity Read ↗

The postnatal role of Sox9 in cartilage.Semantic proximity Read ↗

SOX9 is a regulator of ADAMTSs-induced cartilage degeneration at the early stage of human osteoarthritisSemantic proximity Read ↗

Sox9 is required for cartilage formation.Semantic proximity Read ↗

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