Article
The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9.
Journal of cell science - 1 Nov 2010
Takigawa Yoko, Hata Kenji, Muramatsu Shuji, Amano Katsuhiko, Ono Koichiro, Wakabayashi Makoto, Matsuda Akio, Takada Kenji, Nishimura Riko, Yoneda Toshiyuki
Abstract excerpt
Sox9 is an essential transcription factor for chondrogenesis by regulating the expression of chondrogenic genes. However, its regulatory mechanism is not fully understood. To address this, we attempted to identify the transcriptional partners of Sox9 by screening the cDNA library of the chondrogenic cell line ATDC5 using the collagen 2α1 (Col2α1) gene promoter fused to a luciferase reporter gene. One of the...
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