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Article

SOX9 in organogenesis: shared and unique transcriptional functions.

Cellular and molecular life sciences : CMLS - 17 Sept 2022

Ming Zhenhua, Vining Brittany, Bagheri-Fam Stefan, Harley Vincent

Abstract excerpt

The transcription factor SOX9 is essential for the development of multiple organs including bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human SOX9 gene led to campomelic dysplasia, a haploinsufficiency disorder with several skeletal malformations frequently accompanied by 46, XY sex reversal. The mechanisms underlying the diverse SOX9 functions during organ development...

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Identifiers

PMID: 36114905
DOI: 10.1007/s00018-022-04543-4
PMCID: PMC9482574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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