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Article

Biological activity of activating thyrotrophin receptor mutants: modulation by iodide.

Journal of molecular endocrinology - 1 Feb 2005

Al-Khafaji F, Wiltshire M, Fuhrer D, Mazziotti G, Lewis M D, Smith P J, Ludgate M

Abstract excerpt

Epidemiological studies have revealed a significantly higher incidence of toxic adenoma (TA) and toxic multi-nodular goitre (TMNG) in regions of iodine deficiency. Fifty to eighty percent of TA and TMNG are caused by activation of the cAMP pathway, mostly by mutations in the thyrotrophin receptor (TSHR). We aimed to investigate whether iodide could modulate the biological effects of activating TSHR mutations. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15691889
DOI: 10.1677/jme.1.01590

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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