Article
Pathogenesis of toxic thyroid adenomas and nodules: relevance of activating mutations in the TSH-receptor and Gs-alpha gene, the possible role of iodine deficiency and secondary and TSH-independent molecular mechanisms.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Jan 1998
Derwahl M, Manole D, Sobke A, Broecker M
Abstract excerpt
In iodine deficiency areas, activating mutations in the TSH receptor and Gs-alpha gene are found in the majority of toxic thyroid adenomas and in some toxic goiter nodules. Since TSH receptor and Gs-alpha gene mutations are very rare in areas with high iodine supply, iodine deficiency has been su...
Topics
- Adenoma
- Animals
- Cell Transformation, Neoplastic
- GTP-Binding Proteins
- Goiter, Nodular
- Growth Substances
- Humans
- Iodine
- Mutation
- Oncogenes
- Receptors, Thyrotropin
- Thyroid Neoplasms
- Thyroid Nodule