Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hyperfunctioning thyroid adenoma and activating mutations in the TSH receptor gene.

Archives of medical research - 1 Jan 2000

Polak M

Abstract excerpt

Thyrotropin (TSH) positively controls the function, differentiation, and growth of thyrocytes. TSH interacts with thyrocytes through the TSH receptor and its action is mediated by cyclic AMP-dependent mechanisms. From data gathered on adrenergic receptors, it was hypothesized that TSH receptor mutations that lead to constitutive activation of the TSH receptor would also result in autonomous thyroid growth and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Hyperthyroidism
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Receptors, Thyrotropin

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 10714365
DOI: 10.1016/s0188-4409(99)00067-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyperfunctioning thyroid adenoma and activating mutations in the TSH receptor gene.PMID 10714365Read ↗

Activating mutations of the TSH receptor gene cause thyroid diseases.Semantic proximity Read ↗

Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions.Semantic proximity Read ↗

Activating mutations of TSH receptor.Semantic proximity Read ↗

Constitutive TSH receptor activation as a hallmark of thyroid autonomy.Semantic proximity Read ↗

The TSH receptor and thyroid diseases.Semantic proximity Read ↗

Pathology of the TSH receptor.Semantic proximity Read ↗

A novel activating mutation in the thyrotropin receptor gene in an autonomously functioning thyroid nodule developed by a Japanese patient.Semantic proximity Read ↗

Identification and functional characterization of two new somatic mutations causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroid.Semantic proximity Read ↗

Constitutive activities in the thyrotropin receptor: regulation and significance.Semantic proximity Read ↗

Thyrotropin receptor-associated diseases: from adenomata to Graves disease.Semantic proximity Read ↗

The TSH receptor and its role in thyroid disease.Semantic proximity Read ↗

Thyrotropin receptor: a role for thyroid tumourigenesis?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.