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Article

Constitutive activities in the thyrotropin receptor: regulation and significance.

Advances in pharmacology (San Diego, Calif.) - 1 Jan 2014

Kleinau Gunnar, Biebermann Heike

Abstract excerpt

The thyroid-stimulating hormone receptor (TSHR, or thyrotropin receptor) is a family A G protein-coupled receptor. It not only binds thyroid-stimulating hormone (TSH, or thyrotropin) but also interacts with autoantibodies under pathological conditions. The TSHR and TSH are essential for thyroid growth and function and thus for all thyroid hormone-associated physiological superordinated processes, including...

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Identifiers

PMID: 24931193
DOI: 10.1016/B978-0-12-417197-8.00003-1

Genes

TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Constitutive activities in the thyrotropin receptor: regulation and significance.PMID 24931193Read ↗

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Constitutive activation of the thyroid-stimulating hormone receptor (TSHR) by mutating Ile691 in the cytoplasmic tail segment.Semantic proximity Read ↗

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