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Article

Leucine zipper-mediated homo-oligomerization regulates the Rho-GEF activity of AKAP-Lbc.

The Journal of biological chemistry - 15 Apr 2005

Baisamy Laurent, Jurisch Nathalie, Diviani Dario

Abstract excerpt

AKAP-Lbc is a novel member of the A-kinase anchoring protein (AKAPs) family, which functions as a cAMP-dependent protein kinase (PKA)-targeting protein as well as a guanine nucleotide exchange factor (GEF) for RhoA. We recently demonstrated that AKAP-Lbc Rho-GEF activity is stimulated by the alpha-subunit of the heterotrimeric G protein G(12), whereas phosphorylation of AKAP-Lbc by the anchored PKA induces the...

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Share to 14-3-3 Proteins
Share to A Kinase Anchor Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, G12-G13

Share to Guanine Nucleotide Exchange Factors

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Source

Identifiers

PMID: 15691829
DOI: 10.1074/jbc.M414440200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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