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Article

A-kinase anchoring protein-Lbc promotes pro-fibrotic signaling in cardiac fibroblasts.

Biochimica et biophysica acta - 1 Feb 2014

Cavin Sabrina, Maric Darko, Diviani Dario

Abstract excerpt

In response to stress or injury the heart undergoes an adverse remodeling process associated with cardiomyocyte hypertrophy and fibrosis. Transformation of cardiac fibroblasts to myofibroblasts is a crucial event initiating the fibrotic process. Cardiac myofibroblasts invade the myocardium and secrete excess amounts of extracellular matrix proteins, which cause myocardial stiffening, cardiac dysfunctions and...

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Source

Identifiers

PMID: 24269843
DOI: 10.1016/j.bbamcr.2013.11.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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