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Article

Oligomerization of DH domain is essential for Dbl-induced transformation.

Molecular and cellular biology - 1 Jan 2001

Zhu K, Debreceni B, Bi F, Zheng Y

Abstract excerpt

The dbl oncogene product (onco-Dbl) is the prototype member of a family of guanine nucleotide exchange factors (GEFs) for Rho GTPases. The Dbl homology (DH) domain of onco-Dbl is responsible for the GEF catalytic activity, and the DH domain, together with the immediately adjacent pleckstrin homology (PH) domain, constitutes the minimum module bearing transforming function. In the present study, we demonstrate...

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Identifiers

PMID: 11134331
DOI: 10.1128/MCB.21.2.425-437.2001
PMCID: PMC86589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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