Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification.

The Journal of biological chemistry - 15 Apr 2005

Johnson Kristen A, Terkeltaub Robert A

Abstract excerpt

Chondrocyte maturation to hypertrophy, associated with up-regulated transglutaminase 2 (TG2) expression, mediates not only physiologic growth plate mineralization but also pathologic matrix calcification and dys-regulated matrix repair in osteoarthritic articular cartilage. TG2-/- mouse chondrocytes demonstrate markedly inhibited progression to hypertrophic differentiation in response to both retinoic acid and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cartilage
Share to Chemokine CXCL1
Share to Chemokines, CXC

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type X

Share to Fibronectins

Share to Guanosine Triphosphate

Share to Protein Glutamine gamma Glutamyltransferase 2

Share to Transglutaminases

Source

Identifiers

PMID: 15691824
DOI: 10.1074/jbc.M500962200

Genes

CXCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification.PMID 15691824Read ↗

Mechanism of allosteric regulation of transglutaminase 2 by GTP.Semantic proximity Read ↗

Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity.Semantic proximity Read ↗

Tissue transglutaminase: from biological glue to cell survival cues.Semantic proximity Read ↗

Runx2 Regulates G Protein-coupled Signaling Pathways to Control Growth of Osteoblast ProgenitorsSemantic proximity Read ↗

Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells.Semantic proximity Read ↗

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension.Semantic proximity Read ↗

Targeted inactivation of Gh/tissue transglutaminase II.Semantic proximity Read ↗

Tissue-specific responses to loss of transglutaminase 2.Semantic proximity Read ↗

Establishment of a novel chondrocyte-like cell line derived from transgenic mice harboring the temperature-sensitive simian virus 40 large T-antigen gene.Semantic proximity Read ↗

The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA.Semantic proximity Read ↗

FXIIIA and TGF-beta over-expression produces normal musculo-skeletal phenotype in TG2-/- mice.Semantic proximity Read ↗

Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.