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Article

Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells.

Breast cancer research : BCR - 6 Jan 2012

Kumar Anupam, Xu Jia, Sung Bokyung, Kumar Santosh, Yu Dihua, Aggarwal Bharat B, Mehta Kapil

Abstract excerpt

INTRODUCTION: The expression of proinflammatory protein tissue transglutaminase 2 (TG2) is frequently upregulated in multiple cancer cell types. However, the exact role of TG2 in cancer cells is not well-understood. We recently initiated studies to determine the significance of TG2 in cancer cells and observed that sustained expression of TG2 resulted in epithelial-to-mesenchymal transition (EMT) and promoted...

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Identifiers

PMID: 22225906
DOI: 10.1186/bcr3085
PMCID: PMC3496119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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