Article
FXIIIA and TGF-beta over-expression produces normal musculo-skeletal phenotype in TG2-/- mice.
Amino acids - 1 Apr 2009
Tarantino U, Oliva F, Taurisano G, Orlandi A, Pietroni V, Candi E, Melino G, Maffulli N
Abstract excerpt
Transglutaminase (TGs) enzymes and proteins crosslinking have for long time been implicated in the formation of hard tissue development, matrix maturation and mineralization. Among the TGs family members, in the context of connective tissue formation, TG2 and Factor XIII are expressed in cartilage by hypertrophic chondrocytes. Here, we analyse the morphological consequences of TG2 deficiency, during the...
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