Article
Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal.
The Journal of biological chemistry - 28 Mar 2008
Javed Amjad, Bae Jong-Sup, Afzal Faiza, Gutierrez Soraya, Pratap Jitesh, Zaidi Sayyed K, Lou Yang, van Wijnen Andre J, Stein Janet L, Stein Gary S, Lian Jane B
Abstract excerpt
Two regulatory pathways, bone morphogenetic protein (BMP)/transforming growth factor-beta (TGFbeta) and the transcription factor RUNX2, are required for bone formation in vivo. Here we show the interdependent requirement of these pathways to induce an osteogenic program. A panel of Runx2 deletion and point mutants was used to examine RUNX2-SMAD protein-protein interaction and the biological consequences on...
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