Article
Mechanism of allosteric regulation of transglutaminase 2 by GTP.
Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2006
Begg Gillian E, Carrington Lyle, Stokes Philippa H, Matthews Jacqueline M, Wouters Merridee A, Husain Ahsan, Lorand Laszlo, Iismaa Siiri E, Graham Robert M
Abstract excerpt
Allosteric regulation is a fundamental mechanism of biological control. Here, we investigated the allosteric mechanism by which GTP inhibits cross-linking activity of transglutaminase 2 (TG2), a multifunctional protein, with postulated roles in receptor signaling, extracellular matrix assembly, and apoptosis. Our findings indicate that at least two components are involved in functionally coupling the allosteric...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.