Article
Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension.
Human molecular genetics - 15 Jun 2002
Rudarakanchana Nung, Flanagan Julia A, Chen Hailan, Upton Paul D, Machado Rajiv, Patel D, Trembath Richard C, Morrell Nicholas W
Abstract excerpt
A wide range of mutations in the type II receptor for bone morphogenetic protein (BMPR-II) have been shown to underlie primary pulmonary hypertension. To determine the mechanism of altered BMPR-II function, we employed transient transfection studies in cell lines and primary cultures of pulmonary vascular smooth muscle cells using green fluorescent protein (GFP)-tagged wild-type and mutant BMPR2 constructs and...
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