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Article

Genetic evidence for a protein kinase A/cubitus interruptus complex that facilitates processing of cubitus interruptus in Drosophila.

Genetics - 1 Jul 2001

Kiger J A, O'Shea C

Abstract excerpt

Hedgehog (Hh) activates a signal transduction pathway regulating Cubitus interruptus (Ci). In the absence of Hh, full-length Ci (Ci-155) is bound in a complex that includes Costal2 (Cos2) and Fused (Fu). Ci-155 is phosphorylated by protein kinase A (PKA), inducing proteolysis to Ci-75, a transcriptional repressor. Hh signaling blocks proteolysis and produces an activated Ci-155 transcriptional activator. The...

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Identifiers

PMID: 11454764
DOI: 10.1093/genetics/158.3.1157
PMCID: PMC1461713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence for a protein kinase A/cubitus interruptus complex that facilitates processing of cubitus interruptus in Drosophila.PMID 11454764Read ↗

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.Semantic proximity Read ↗

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.Semantic proximity Read ↗

Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.Semantic proximity Read ↗

Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing.Semantic proximity Read ↗

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.Semantic proximity Read ↗

Genetic dissection of the Drosophila Cubitus interruptus signaling complex.Semantic proximity Read ↗

Ci: a complex transducer of the hedgehog signal.Semantic proximity Read ↗

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.Semantic proximity Read ↗

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An absolute requirement for Cubitus interruptus in Hedgehog signaling.Semantic proximity Read ↗

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