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Article

SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.

Developmental cell - 1 May 2004

Grieshammer Uta, Le Ma, Plump Andrew S, Wang Fan, Tessier-Lavigne Marc, Martin Gail R

Abstract excerpt

Kidney development occurs in a stereotypic position along the body axis. It begins when a single ureteric bud emerges from the nephric duct in response to GDNF secreted by the adjacent nephrogenic mesenchyme. Posterior restriction of Gdnf expression is considered critical for correct positioning of ureteric bud development. Here we show that mouse mutants lacking either SLIT2 or its receptor ROBO2, molecules...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15130495
DOI: 10.1016/s1534-5807(04)00108-x

Genes

ROBO2
SLIT2
GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.PMID 15130495Read ↗

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