The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney.

doi:10.1016/j.ydbio.2011.09.029

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Article

The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney.

Developmental biology - 15 Dec 2011

Willecke Regina, Heuberger Julian, Grossmann Katja, Michos Odyssé, Schmidt-Ott Kai, Walentin Katharina, Costantini Frank, Birchmeier Walter

Abstract excerpt

The tyrosine phosphatase Shp2 acts downstream of various growth factors, hormones or cytokine receptors. Mutations of the Shp2 gene are associated with several human diseases. Here we have ablated Shp2 in the developing kidneys of mice, using the ureteric bud epithelium-specific Hoxb7/Cre. Mutant mice produced a phenotype that is similar to mutations of the genes of the GDNF/Ret receptor system, that is: strongly...

Topics

Adaptor Proteins, Signal Transducing
Animals
Cell Proliferation
DNA-Binding Proteins
Female
Glial Cell Line-Derived Neurotrophic Factor
Homeodomain Proteins
Kidney
Male
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Morphogenesis

Mutation

Nuclear Proteins

Phosphoproteins

Protein Tyrosine Phosphatase, Non-Receptor Type 11

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 22015719
DOI: 10.1016/j.ydbio.2011.09.029

Genes

GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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