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Article

Development of the urogenital system is regulated via the 3′UTR of GDNF

28 Mar 2019

Abstract excerpt

Abstract Mechanisms controlling ureter lenght and the position of the kidney are poorly understood. Glial cell-line derived neurotrophic factor (GDNF) induced RET signaling is critical for ureteric bud outgrowth, but the function of endogenous GDNF in further renal differentiation and urogenital system development remains discursive. Here we analyzed mice where 3′ untranslated region (UTR) of GDNF is replaced...

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PMID: 30923332
DOI: 10.1038/s41598-019-40457-1

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