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Article

Proteolytic cleavage of pertussis toxin S1 subunit is not essential for its activity in mammalian cells.

BMC microbiology - 3 Feb 2005

Carbonetti Nicholas H, Mays R Michael, Artamonova Galina V, Plaut Roger D, Worthington Zoë E V

Abstract excerpt

BACKGROUND: Pertussis toxin (PT) is an exotoxin virulence factor produced by Bordetella pertussis, the causative agent of whooping cough. PT consists of an active subunit (S1) that ADP-ribosylates the alpha subunit of several mammalian G proteins, and a B oligomer (S2-S5) that binds glycoconjugate receptors on cells. PT appears to enter cells by endocytosis, and retrograde transport through the Golgi apparatus...

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Identifiers

PMID: 15691377
DOI: 10.1186/1471-2180-5-7
PMCID: PMC550662

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Source receipt: pubmed, retrieved 7 Sept 2026.

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