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Article

Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus.

Biochemical and biophysical research communications - 21 Jan 2005

Bergeron Eric, Vincent Martin J, Wickham Louise, Hamelin Josée, Basak Ajoy, Nichol Stuart T, Chrétien Michel, Seidah Nabil G

Abstract excerpt

Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of SARS. Analysis of SARS-CoV spike glycoprotein (S) using recombinant plasmid and virus infections demonstrated that the S-precursor (proS) exists as a approximately 190 kDa endoplasmic reticulum form and a approximately 210 kDa Golgi-modified form. ProS is subsequently processed into two C-terminal proteins of approximately 110...

Topics

Animals
Chlorocebus aethiops
Furin
Humans
Mutation
Proprotein Convertase 5
Proprotein Convertases
Severe acute respiratory syndrome-related coronavirus
Severe Acute Respiratory Syndrome
Subtilisins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vero Cells

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Identifiers

PMID: 15596135
DOI: 10.1016/j.bbrc.2004.11.063
PMCID: PMC7092861

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