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Article

Contribution of pertussis toxin to the pathogenesis of pertussis disease: Graphical Abstract Figure.

21 Sept 2015

Abstract excerpt

Pertussis toxin (PT) is a multisubunit protein toxin secreted by Bordetella pertussis, the bacterial agent of the disease pertussis or whooping cough. PT in detoxified form is a component of all licensed acellular pertussis vaccines, since it is considered to be an important virulence factor for this pathogen. PT inhibits G protein-coupled receptor signaling through Gi proteins in mammalian cells, an activity...

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PMID: 26394801
DOI: 10.1093/femspd/ftv073

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