DsbA and DsbC are required for secretion of pertussis toxin by Bordetella pertussis.

doi:10.1128/IAI.70.5.2297-2303.2002

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Article

DsbA and DsbC are required for secretion of pertussis toxin by Bordetella pertussis.

Infection and immunity - 1 May 2002

Stenson Trevor H, Weiss Alison A

Abstract excerpt

The Dsb family of enzymes catalyzes disulfide bond formation in the gram-negative periplasm, which is required for folding and assembly of many secreted proteins. Pertussis toxin is arguably the most complex toxin known: it is assembled from six subunits encoded by five genes (for subunits S1 to S5), with 11 intramolecular disulfide bonds. To examine the role of the Dsb enzymes in assembly and secretion of...

Topics

Animals
Bacterial Proteins
Bordetella pertussis
CHO Cells
Cricetinae
Membrane Proteins
Mutation
Pertussis Toxin
Protein Disulfide-Isomerases
Virulence Factors, Bordetella

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Identifiers

PMID: 11953363
DOI: 10.1128/IAI.70.5.2297-2303.2002
PMCID: PMC127938

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