Article
The subunit S1 is important for pertussis toxin secretion.
The Journal of biological chemistry - 15 Oct 1990
Pizza M, Bugnoli M, Manetti R, Covacci A, Rappuoli R
Abstract excerpt
Pertussis toxin is a protein containing five noncovalently linked subunits which are assembled into the monomer A (containing the subunit S1) and the oligomer B (containing subunits S2, S3, S4, and S5 in a 1:1:2:1 ratio). Each of the five subunits is synthesized as a precursor containing a secretory leader peptide and is secreted into the periplasm of Bordetella pertussis where the five subunits are assembled...
Topics
- Base Sequence
- Blotting, Western
- Bordetella pertussis
- Electrophoresis, Polyacrylamide Gel
- Macromolecular Substances
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Oligonucleotide Probes
- Pertussis Toxin
- Protein Sorting Signals