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Article

The subunit S1 is important for pertussis toxin secretion.

The Journal of biological chemistry - 15 Oct 1990

Pizza M, Bugnoli M, Manetti R, Covacci A, Rappuoli R

Abstract excerpt

Pertussis toxin is a protein containing five noncovalently linked subunits which are assembled into the monomer A (containing the subunit S1) and the oligomer B (containing subunits S2, S3, S4, and S5 in a 1:1:2:1 ratio). Each of the five subunits is synthesized as a precursor containing a secretory leader peptide and is secreted into the periplasm of Bordetella pertussis where the five subunits are assembled...

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PMID: 2211659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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The subunit S1 is important for pertussis toxin secretion.PMID 2211659Read ↗

Mutations in the S1 subunit of pertussis toxin that affect secretion.Semantic proximity Read ↗

Analysis of subassemblies of pertussis toxin subunits in vivo and their interaction with the ptl transport apparatus.Semantic proximity Read ↗

DsbA and DsbC are required for secretion of pertussis toxin by Bordetella pertussis.Semantic proximity Read ↗

Proteolytic cleavage of pertussis toxin S1 subunit is not essential for its activity in mammalian cells.Semantic proximity Read ↗

Molecular characterization of an operon required for pertussis toxin secretion.Semantic proximity Read ↗

Pertussis toxin export requires accessory genes located downstream from the pertussis toxin operon.Semantic proximity Read ↗

Contribution of pertussis toxin to the pathogenesis of pertussis disease: Graphical Abstract Figure.Semantic proximity Read ↗

The History of Pertussis ToxinSemantic proximity Read ↗

Mutants in the ptlA-H genes of Bordetella pertussis are deficient for pertussis toxin secretion.Semantic proximity Read ↗

Biochemical analysis of mutations at tyrosine-98 of the S1 subunit of pertussis toxin.Semantic proximity Read ↗

Expression, activity and cytotoxicity of pertussis toxin S1 subunit in transfected mammalian cells.Semantic proximity Read ↗

A critical new pathway for toxin secretion?Semantic proximity Read ↗

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