Clostridium septicum alpha-toxin is proteolytically activated by furin.

doi:10.1128/iai.65.10.4130-4134.1997

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Article

Clostridium septicum alpha-toxin is proteolytically activated by furin.

Infection and immunity - 1 Oct 1997

Gordon V M, Benz R, Fujii K, Leppla S H, Tweten R K

Abstract excerpt

Clostridium septicum alpha-toxin is secreted as an inactive 46,450-Da protoxin. The protoxin is activated by proteolytic cleavage near the C terminus, which eventually causes the release of a 45-amino-acid fragment. Proteoytic activation and loss of the propeptide allow alpha-toxin to oligomerize...

Topics

Animals
Antipain
Bacterial Toxins
CHO Cells
Clostridium
Cricetinae
Cysteine Proteinase Inhibitors
Dose-Response Relationship, Drug
Furin
Hemolysis
Mutation
Propidium
Protein Processing, Post-Translational
Recombinant Proteins
Subtilisins
Toxicity Tests
Trypsin

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