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Article

Clostridium septicum alpha-toxin is proteolytically activated by furin.

Infection and immunity - 1 Oct 1997

Gordon V M, Benz R, Fujii K, Leppla S H, Tweten R K

Abstract excerpt

Clostridium septicum alpha-toxin is secreted as an inactive 46,450-Da protoxin. The protoxin is activated by proteolytic cleavage near the C terminus, which eventually causes the release of a 45-amino-acid fragment. Proteoytic activation and loss of the propeptide allow alpha-toxin to oligomerize and form pores on the plasma membrane, which results in colloidal-osmotic lysis. Activation may be accomplished in...

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Identifiers

PMID: 9317018
DOI: 10.1128/iai.65.10.4130-4134.1997
PMCID: PMC175594

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