Article
Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism.
PLoS pathogens - 1 Jan 2012
Chumbler Nicole M, Farrow Melissa A, Lapierre Lynne A, Franklin Jeffrey L, Haslam David B, Haslam David, Goldenring James R, Lacy D Borden
Abstract excerpt
Clostridium difficile is the most common cause of antibiotic-associated nosocomial infection in the United States. C. difficile secretes two homologous toxins, TcdA and TcdB, which are responsible for the symptoms of C. difficile associated disease. The mechanism of toxin action includes an autoprocessing event where a cysteine protease domain (CPD) releases a glucosyltransferase domain (GTD) into the cytosol....
Topics
- Animals
- Bacterial Proteins
- Bacterial Toxins
- Caco-2 Cells
- Clostridioides difficile
- Enterocolitis, Pseudomembranous
- Epithelial Cells
- Female
- HeLa Cells
- Humans
- Male