Article
Transgenic expression of CCK2 receptors sensitizes murine pancreatic acinar cells to carcinogen-induced preneoplastic lesions formation.
International journal of cancer - 20 May 2005
Mathieu Anne, Clerc Pascal, Portolan Ghislaine, Bierkamp Christiane, Lulka Hubert, Pradayrol Lucien, Seva Catherine, Fourmy Daniel, Dufresne Marlène
Abstract excerpt
In humans, initial events of pancreatic carcinogenesis remain unknown, and the question of whether this cancer, which has a ductal phenotype, exclusively arises from duct cells has been raised. Previous studies have demonstrated that transgenic expression of the CCK2 receptor in acinar cells of ElasCCK2 mice plays a role in the development of pancreatic neoplasia. The aim of our study was to examine initial steps...
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