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Article

Precancerous lesions upon sporadic activation of beta-catenin in mice.

Gastroenterology - 1 Apr 2007

Coste Isabelle, Freund Jean-Noël, Spaderna Simone, Brabletz Thomas, Renno Toufic

Abstract excerpt

BACKGROUND & AIMS: Inappropriate activation of beta-catenin in adult tissues is associated with a wide variety of cancers, especially in the digestive tract. Classic transgenic and knockout murine models in which beta-catenin is activated in large fields of cells have provided experimental support in favor of a role for this molecule in tumorigenesis. However, these models do not reproduce the sporadic nature of...

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Identifiers

PMID: 17408631
DOI: 10.1053/j.gastro.2007.01.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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