Article
Evaluation of the Tg.AC transgenic mouse assay for testing the human carcinogenic potential of pharmaceuticals--practical pointers, mechanistic clues, and new questions.
International journal of toxicology - 1 Jan 2000
Sistare Frank D, Thompson Karol L, Honchel Ronald, DeGeorge Joseph
Abstract excerpt
Transgenic mouse strains with genetic alterations known to play a role in the multistage process of carcinogenesis are being used increasingly as models for evaluating the human carcinogenic potential of chemicals and pharmaceuticals. The Tg.AC transgenic mouse is one of the strains currently being used in such alternative short-term carcinogenicity testing protocols. This review is focused on recent data from...
Topics
- Animal Testing Alternatives
- Animals
- Carcinogenicity Tests
- Carcinogens
- Disease Models, Animal
- Drug-Related Side Effects and Adverse Reactions
- Genes, ras
- Genotype
- Humans
- Mice
- Mice, Transgenic
- Papilloma
- Skin Neoplasms