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Loss of Heterozygosity Occurs via Mitotic Recombination in Trp53 +/− Mice and Associates with Mammary Tumor Susceptibility of the BALB/c Strain

1 Aug 2004

Abstract excerpt

Loss of heterozygosity (LOH) occurs commonly in cancers causing disruption of tumor suppressor genes and promoting tumor progression. BALB/c-Trp53(+/-) mice are a model of Li-Fraumeni syndrome, exhibiting a high frequency of mammary tumors and other tumor types seen in patients. However, the frequency of mammary tumors and LOH differs among strains of Trp53(+/-) mice, with mammary tumors occurring only on a...

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PMID: 15289317
DOI: 10.1158/0008-5472.can-03-3435

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