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Article

PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.

Genes & development - 1 Feb 2005

Mäkinen Taija, Adams Ralf H, Bailey John, Lu Qiang, Ziemiecki Andrew, Alitalo Kari, Klein Rüdiger, Wilkinson George A

Abstract excerpt

The transmembrane ligand ephrinB2 and its cognate Eph receptor tyrosine kinases are important regulators of embryonic blood vascular morphogenesis. However, the molecular mechanisms required for ephrinB2 transduced cellular signaling in vivo have not been characterized. To address this question, we generated two sets of knock-in mice: ephrinB2DeltaV mice expressed ephrinB2 lacking the C-terminal PDZ interaction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15687262
DOI: 10.1101/gad.330105
PMCID: PMC546518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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