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Essential roles of EphrinB2 in mammalian heart: from development to diseases

25 Mar 2019

Abstract excerpt

EphrinB2, a membrane-tethered ligand preferentially binding to its receptor EphB4, is ubiquitously expressed in all mammals. Through the particular bidirectional signaling, EphrinB2 plays a critical role during the development of cardiovascular system, postnatal angiogenesis physiologically and pathologically, and cardiac remodeling after injuries as an emerging role. This review highlights the pivotal...

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PMID: 30909943
DOI: 10.1186/s12964-019-0337-3

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