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Article

The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk.

Angiogenesis - 1 May 2021

Mauri Cristina, van Impel Andreas, Mackay Eirinn William, Schulte-Merker Stefan

Abstract excerpt

Vegfc/Vegfr3 signaling is critical for lymphangiogenesis, the sprouting of lymphatic vessels. In zebrafish, cells sprouting from the posterior cardinal vein can either form lymphatic precursor cells or contribute to intersegmental vein formation. Both, the Vegfc-dependent differential induction of Prox1a in sprouting cells as well as a Notch-mediated pre-pattern within intersegmental vessels have been associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33677657
DOI: 10.1007/s10456-021-09774-w
PMCID: PMC8205915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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