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Article

Murine Notch1 is required for lymphatic vascular morphogenesis during development

22 Mar 2014

Abstract excerpt

BACKGROUND: The transmembrane receptor Notch1 is a critical regulator of arterial differentiation and blood vessel sprouting. Recent evidence shows that functional blockade of Notch1 and its ligand, Dll4, leads to postnatal lymphatic defects in mice. However, the precise role of the Notch signaling pathway in lymphatic vessel development has yet to be defined. Here we show the developmental role of Notch1 in...

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PMID: 24659232
DOI: 10.1002/dvdy.24129

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