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Article

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2

1 Jun 2015

Abstract excerpt

The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show that cyclin-dependent kinase 5 (Cdk5) is an essential regulator of lymphatic vessel development. Endothelial-specific Cdk5 knockdown causes congenital lymphatic...

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PMID: 26027726
DOI: 10.1038/ncomms8274

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