Article
Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice.
The Journal of clinical investigation - 1 Aug 2011
Bazigou Eleni, Lyons Oliver T A, Smith Alberto, Venn Graham E, Cope Celia, Brown Nigel A, Makinen Taija
Abstract excerpt
Chronic venous disease and venous hypertension are common consequences of valve insufficiency, yet the molecular mechanisms regulating the formation and maintenance of venous valves have not been studied. Here, we provide what we believe to be the first description of venous valve morphogenesis and identify signaling pathways required for the process. The initial stages of valve development were found to involve...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.