Article
Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn's disease.
Gastroenterology - 1 Feb 2005
Sugawara Kazuhiko, Olson Timothy S, Moskaluk Christopher A, Stevens Brian K, Hoang Sharon, Kozaiwa Kosuke, Cominelli Fabio, Ley Klaus F, McDuffie Marcia
Abstract excerpt
BACKGROUND AND AIMS: Genetic predisposition is implicated strongly in Crohn's disease. Disease-associated mutations in NOD2/CARD15 , the best-studied susceptibility gene in this disorder, explain only a small fraction of the heritability. The SAMP1/YitFc (SAMP1/Fc) mouse strain expresses many features of Crohn's disease in humans. We bred SAMP1/Fc to disease-resistant AKR mice to identify additional...
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