Article
Functional Analyses of the Crohn's Disease Risk Gene LACC1.
PloS one - 1 Jan 2016
Assadi Ghazaleh, Vesterlund Liselotte, Bonfiglio Ferdinando, Mazzurana Luca, Cordeddu Lina, Schepis Danika, Mjösberg Jenny, Ruhrmann Sabrina, Fabbri Alessia, Vukojevic Vladana, Percipalle Piergiorgio, Salomons Florian A, Laurencikiene Jurga, Törkvist Leif, Halfvarson Jonas, D'Amato Mauro
Abstract excerpt
BACKGROUND: Genetic variation in the Laccase (multicopper oxidoreductase) domain-containing 1 (LACC1) gene has been shown to affect the risk of Crohn's disease, leprosy and, more recently, ulcerative colitis and juvenile idiopathic arthritis. LACC1 function appears to promote fatty-acid oxidation, with concomitant inflammasome activation, reactive oxygen species production, and anti-bacterial responses in...
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