Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon.

doi:10.1073/pnas.0905745107

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Article

Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon.

Proceedings of the National Academy of Sciences of the United States of America - 11 May 2010

Peyrin-Biroulet Laurent, Beisner Julia, Wang Guoxing, Nuding Sabine, Oommen Sajit Thottathil, Kelly Denise, Parmentier-Decrucq Erika, Dessein Rodrigue, Merour Emilie, Chavatte Philipe, Grandjean Teddy, Bressenot Aude, Desreumaux Pierre, Colombel Jean-Frédéric, Desvergne Béatrice, Stange Eduard F, Wehkamp Jan, Chamaillard Mathias

Abstract excerpt

Crohn's disease (CD), a major form of human inflammatory bowel disease, is characterized by primary immunodeficiencies. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is essential for intestinal homeostasis in response to both dietary- and microbiota-derived signals. Its role in host defense remains unknown, however. We show that PPARgamma functions as an antimicrobial factor by...

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PMID: 20421464
DOI: 10.1073/pnas.0905745107
PMCID: PMC2889363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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