Article
NR4A1 modulates intestinal smooth muscle cell phenotype and dampens inflammation-associated intestinal remodeling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2022
Szczepanski Holly E, Flannigan Kyle L, Mainoli Barbara, Alston Laurie, Baruta Grace M, Lee Joshua W, Venu Vivek Krishna Pulakazhi, Shearer Jane, Dufour Antoine, Hirota Simon A
Abstract excerpt
Stricture formation is a common complication of Crohn's disease (CD), driven by enhanced deposition of extracellular matrix (ECM) and expansion of the intestinal smooth muscle layers. Nuclear receptor subfamily 4 group A member 1 (NR4A1) is an orphan nuclear receptor that exhibits anti-proliferative effects in smooth muscle cells (SMCs). We hypothesized that NR4A1 regulates intestinal SMC proliferation and muscle...
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