Article
Novel model of TH2-polarized chronic ileitis: the SAMP1 mouse.
Inflammatory bowel diseases - 1 May 2010
McNamee Eoin N, Wermers Joshua D, Masterson Joanne C, Collins Colm B, Lebsack Matthew D P, Fillon Sophie, Robinson Zachary D, Grenawalt Joanna, Lee James J, Jedlicka Paul, Furuta Glenn T, Rivera-Nieves Jesçs
Abstract excerpt
BACKGROUND: SAMP1/Yit mice develop spontaneous, segmental, transmural ileitis recapitulating many features of Crohn's disease (CD). The ileitic phenotype may have arisen during crosses of SAMP1 mice selected for the presence of skin lesions. We hereby describe that the original SAMP1 strain simil...
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