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Article

Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's disease: SAMP1/YitFc.

Gastroenterology - 1 Aug 2003

Kozaiwa Kosuke, Sugawara Kazuhiko, Smith Michael F, Carl Virginia, Yamschikov Vladimir, Belyea Brian, McEwen Sherri B, Moskaluk Christopher A, Pizarro Theresa T, Cominelli Fabio, McDuffie Marcia

Abstract excerpt

BACKGROUND & AIMS: The SAMP1/Yit mouse strain develops spontaneous ileitis with histologic features of Crohn's disease. Disease expression in the SAMP1/YitFc subline (SAMP1/Fc) is partially inhibited by outcross to C57BL/6J (B6) mice, suggesting complex genetic control of disease susceptibility with both dominant and recessive determinants. We performed a genetic analysis of a (B6 x SAMP1/Fc)F(2) cross to...

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Identifiers

PMID: 12891551
DOI: 10.1016/s0016-5085(03)00876-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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