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Comprehensive functional characterization of rare and known CYP2E1 allelic variants identified in a Japanese population.

Biochemical pharmacology - 1 Dec 2025

Ohmori Yuki, Hishinuma Eiji, Suzuki Yuma, Ueda Akiko, Kijogi Caroline Mwendwa, Nakayoshi Tomoki, Oda Akifumi, Saito Sakae, Tadaka Shu, Kinoshita Kengo, Sato Yu, Hiratsuka Masahiro

Abstract excerpt

Cytochrome P450 2E1 (CYP2E1) is a key hepatic enzyme involved in the oxidative metabolism of low-molecular-weight xenobiotics, including drugs, anesthetics, and procarcinogens. Although numerous CYP2E1 genetic variants have been identified, their functional implications remain unclear. In this study, we systematically characterized 25 CYP2E1 variants-22 novel missense variants identified via whole-genome...

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PMID: 41047031
DOI: 10.1016/j.bcp.2025.117396

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CYP2E1

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