Article
Cdx binding determines the timing of enhancer activation in postnatal duodenum.
The Journal of biological chemistry - 1 Apr 2005
Maier Elizabeth A, Dusing Mary R, Wiginton Dan A
Abstract excerpt
In mammalian intestine, adenosine deaminase (ADA) is expressed at high levels only along the villi of the duodenal epithelium. A duodenum-specific enhancer identified in the second intron of the human ADA gene controls this pattern of expression. This enhancer faithfully recapitulates this expression pattern in transgenic mice, when included in CAT reporter gene constructions. Multiple binding sites for PDX-1 and...
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