Article
High-level activation by a duodenum-specific enhancer requires functional GATA binding sites.
American journal of physiology. Gastrointestinal and liver physiology - 1 Jun 2003
Dusing Mary R, Florence Elizabeth A, Wiginton Dan A
Abstract excerpt
The purine metabolic gene adenosine deaminase (ADA) is expressed at high levels in a well-defined spatiotemporal pattern in the villous epithelium of proximal small intestine. A duodenum-specific enhancer module responsible for this expression pattern has been identified in the second intron of the human ADA gene. It has previously been shown that binding of the factor PDX-1 is essential for function of this...
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