Article
Pdx-1 is required for activation in vivo from a duodenum-specific enhancer.
The Journal of biological chemistry - 27 Apr 2001
Dusing M R, Florence E A, Wiginton D A
Abstract excerpt
The purine metabolic gene adenosine deaminase (ADA) is expressed along a defined spatiotemporal pattern in the developing mammalian small intestine, where high-level expression is limited to the villous epithelium of the duodenum. This activation is observed in rodents as the intestine completes the final maturation resulting in adult crypt-villus structures at 2-3 weeks postpartum. A regulatory module...
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