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Article

Pdx-1 is required for activation in vivo from a duodenum-specific enhancer.

The Journal of biological chemistry - 27 Apr 2001

Dusing M R, Florence E A, Wiginton D A

Abstract excerpt

The purine metabolic gene adenosine deaminase (ADA) is expressed along a defined spatiotemporal pattern in the developing mammalian small intestine, where high-level expression is limited to the villous epithelium of the duodenum. This activation is observed in rodents as the intestine completes...

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Topics

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Share to Adenosine Deaminase
Share to Amino Acid Motifs
Share to CHO Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Duodenum

Share to Enhancer Elements, Genetic

Share to Intestinal Mucosa

Share to Protein Biosynthesis

Share to Transgenes

Source

Identifiers

PMID: 11278481
DOI: 10.1074/jbc.M009249200

Genes

ADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11278481-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pdx-1 is required for activation in vivo from a duodenum-specific enhancer.PMID 11278481Read ↗

High-level activation by a duodenum-specific enhancer requires functional GATA binding sites.Semantic proximity Read ↗

Cdx binding determines the timing of enhancer activation in postnatal duodenum.Semantic proximity Read ↗

Conserved Transcriptional Regulatory Domains of the pdx-1 GeneSemantic proximity Read ↗

Diverse genetic regulatory motifs required for murine adenosine deaminase gene expression in the placenta.Semantic proximity Read ↗

Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood.Semantic proximity Read ↗

Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression.Semantic proximity Read ↗

Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1.Semantic proximity Read ↗

Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice.Semantic proximity Read ↗

Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.Semantic proximity Read ↗

Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1.Semantic proximity Read ↗

Regulation of pdx-1 Gene ExpressionSemantic proximity Read ↗

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