Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Nkx-dependent enhancer regulates cGATA-6 gene expression during early stages of heart development.

Developmental biology - 15 Jan 2000

Davis D L, Wessels A, Burch J B

Abstract excerpt

The evolutionarily conserved GATA-6 transcription factor is an early and persistent marker of heart development in diverse vertebrate species. We previously found evidence for a functionally conserved heart-specific enhancer upstream of the chicken GATA-6 (cGATA-6) gene and in the present study we used transgenic mouse assays to further characterize this regulatory module. We show that this enhancer is activated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation
Share to Cell Lineage
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GATA6 Transcription Factor

Share to Homeobox Protein Nkx-2.5

Share to Homeodomain Proteins

Share to Xenopus Proteins

Source

Identifiers

PMID: 10625556
DOI: 10.1006/dbio.1999.9561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Nkx-dependent enhancer regulates cGATA-6 gene expression during early stages of heart development.PMID 10625556Read ↗

Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.Semantic proximity Read ↗

A GATA-dependent right ventricular enhancer controls <i>dHAND</i> transcription in the developing heartSemantic proximity Read ↗

Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5.Semantic proximity Read ↗

Distal enhancers: new insights into heart development and disease.Semantic proximity Read ↗

Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.Semantic proximity Read ↗

The transcription factor Foxc1a in zebrafish directly regulates expression of nkx2.5, encoding a transcriptional regulator of cardiac progenitor cellsSemantic proximity Read ↗

An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow TractSemantic proximity Read ↗

Fish-Ing for Enhancers in the Heart.Semantic proximity Read ↗

Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF.Semantic proximity Read ↗

The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer.Semantic proximity Read ↗

Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart.Semantic proximity Read ↗

GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.