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Article

Regulation of pdx-1 Gene Expression

1 Dec 2002

Abstract excerpt

The homeodomain-containing transcription factor pancreatic duodenal homeobox 1 (PDX-1) plays a key role in pancreas development and in beta-cell function. Upstream sequences of the gene up to about -6 kb show islet-specific activity in transgenic mice. Attempts to identify functional regulatory elements involved in the controlled expression of the pdx-1 gene led to the identification of distinct distal...

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Identifiers

PMID: 12475770
DOI: 10.2337/diabetes.51.2007.s320

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