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Article

Conserved Transcriptional Regulatory Domains of the pdx-1 Gene

6 Jan 2004

Abstract excerpt

The pancreas and duodenum homeobox protein 1 (PDX-1) homeodomain-containing transcription factor affects both pancreatic endocrine cell development and adult islet beta-cell function. Cell-type-specific expression is controlled by sequences 5' flanking the pdx-1 gene transcription start site. One principal control region is located roughly between -2800 and -1600 bp and spans three conserved, distinct, and...

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Identifiers

PMID: 14701942
DOI: 10.1210/me.2003-0371

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